One problem in this video

Otherwise it is great.

Chimp-Human DNA: Less similar than previously reported
CMI Video | 9 Nov. 2022
https://www.youtube.com/watch?v=nlNLoEGu0po

But watch this, the comments were also left on the video:

18:37 Actually, there is empirical evidence how chromosome fusion could happen.

Mice in general have 40 chromosomes. Mice on Mallorca have 22.

The obvious implication is that some chromosomes fused.

Similarily, European hares and European rabbits are two chrosome pair numbers apart. There is a North American species which has the intermediate chromosome number and can mate with both, which our hares and rabbits can't between them.

The obvious implication is that some chromosomes fused. If you believe in baraminology - which I do - you would be hard set to deny this.

The REAL problem for Evolutionists is, how could a creature acquire more chromosomes than its ancestor.

P Z Myers gave diagrams for his theory, and the post is still up, but the diagrams are replaced with symbols saying "there used to be an image here" ...

He didn't mark telomeres on the diagram. His option would have involved the split between two centremeres (doubling event previous to this) leading to "naked" arms not protected by telomeres, as far as I can see.

I was given one possible answer, but have not been able to check it. Telomeres, on this view, aren't inherited but given at the meiosis or whatever the process is called.

18:49 Chromosome fissions with bare arms lacking telomeres are definitely also a thing for cancers.

21:47 Downs Syndrome is actually not a locus mutation, not a copying mistake.

But the study of karyogrammic mutations and their consequences show that the idea of animals developing more couples of chromosomes by this way is out.

Imagine two people with Downs get together, each providing a gamete not with one but with two chromosomes 21, and an offspring has 4 such. The thing is, tetrasomy 21 is an even worse condition than just trisomy 21. Meaning, this too is also a non-path for explaining how mammals could acquire more chromosomes than the first mammal (triploidy, tetraploidy as viable variants are not a thing in mammals).

21:53 Actually, lactose intolerance is the normal human condition above a certain age.

Lactase persistence is the mutation.

However, while lactase persistence is beneficial, it is a loss of function, the original having two informations - 1) setting on the lactase production so the mammal can profit from lactation, 2) shutting it off after the age of lactation. The mutation has meant this second part is garbled, so the production of lactase is continued by default.